Prof. dr. H.V. (Hans) Westerhoff
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
- Science Park 904
Postadres
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Postbus 1212
1000 BE Amsterdam
Contactgegevens
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Publicaties
2023
Bruggeman, F. J., Remeijer, M., Droste, M., Salinas, L., Wortel, M., Planqué, R., Sauro, H. M., Teusink, B., & Westerhoff, H. V. (2023). Whole-cell metabolic control analysis. Biosystems, 234, Article 105067. https://doi.org/10.1016/j.biosystems.2023.105067 [details]- Goldberg, R. N., Giessmann, R. T., Halling, P. J., Kettner, C., & Westerhoff, H. V. (2023). Recommendations for performing measurements of apparent equilibrium constants of enzyme-catalyzed reactions and for reporting the results of these measurements. Beilstein Journal of Organic Chemistry, 19, 303-316. https://doi.org/10.3762/bjoc.19.26 [details]
- Hassan, Z., Braster, M., Röling, W. F. M., & Westerhoff, H. V. (2023). Microbes-Assisted Arsenate Reduction Activity in Bangladesh Drinking Water Wells as Revealed by Enrichment Cultivation. Geomicrobiology Journal, 40(2), 161-171. https://doi.org/10.1080/01490451.2022.2133195 [details]
- Liu, Y., & Westerhoff, H. V. (2023). Competitive, multi-objective, and compartmented Flux Balance Analysis for addressing tissue-specific inborn errors of metabolism. Journal of inherited metabolic disease, 46(4), 573-585. https://doi.org/10.1002/jimd.12603 [details]
- Liu, Y., & Westerhoff, H. V. (2023). ‘Social’ versus ‘asocial’ cells—dynamic competition flux balance analysis. Npj Systems Biology and Applications, 9, Article 53. https://doi.org/10.1038/s41540-023-00313-5 [details]
- Westerhoff, H. V. (2023). On paradoxes between optimal growth, metabolic control analysis, and flux balance analysis. Biosystems, 233, Article 104998. https://doi.org/10.1016/j.biosystems.2023.104998 [details]
- Westerhoff, H. V. (2023). Summation Laws in Control of Biochemical Systems. Mathematics, 11(11), Article 2473. https://doi.org/10.3390/math11112473
- Zhang, Y., & Westerhoff, H. V. (2023). Gear Shifting in Biological Energy Transduction. Entropy, 25(7), Article 993. https://doi.org/10.3390/e25070993 [details]
- van Niekerk, D. D., Rust, E., Bruggeman, F., Westerhoff, H. V., & Snoep, J. L. (2023). Is distance from equilibrium a good indicator for a reaction's flux control? Biosystems, 232, Article 104988. https://doi.org/10.1016/j.biosystems.2023.104988 [details]
2021
- Verstegen, N. J. M., Ubels, V., Westerhoff, H. V., van Ham, S. M., & Barberis, M. (2021). System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation. Frontiers in Immunology, 12, Article 734282. https://doi.org/10.3389/fimmu.2021.734282 [details]
- Weglarz-Tomczak, E., Mondeel, T. D. G. A., Piebes, D. G. E., & Westerhoff, H. V. (2021). Simultaneous integration of gene expression and nutrient availability for studying the metabolism of hepatocellular carcinoma cell lines. BIOMOLECULES, 11(4), Article 490. https://doi.org/10.3390/biom11040490 [details]
2020
- Abudukelimu, A., Barberis, M., Redegeld, F., Sahin, N., Sharma, R. P., & Westerhoff, H. V. (2020). Complex Stability and an Irrevertible Transition Reverted by Peptide and Fibroblasts in a Dynamic Model of Innate Immunity. Frontiers in Immunology, 10, Article 3091. https://doi.org/10.3389/fimmu.2019.03091 [details]
- Kolodkin, A. N., Sharma, R. P., Colangelo, A. M., Ignatenko, A., Martorana, F., Jennen, D., Briedé, J. J., Brady, N., Barberis, M., Mondeel, T. D. G. A., Papa, M., Kumar, V., Peters, B., Skupin, A., Alberghina, L., Balling, R., & Westerhoff, H. V. (2020). ROS networks: Designs, aging, Parkinson's disease and precision therapies. Npj Systems Biology and Applications, 6, Article 34. https://doi.org/10.1038/s41540-020-00150-w [details]
- Mondeel, T. D. G. A., Ivanov, O., Westerhoff, H. V., Liebermeister, W., & Barberis, M. (2020). Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs. Npj Systems Biology and Applications, 6, Article 8. https://doi.org/10.1038/s41540-020-0125-0 [details]
- Sharma, R. P., Kumar, V., Schuhmacher, M., Kolodkin, A., & Westerhoff, H. V. (2020). Development and evaluation of a harmonized whole body physiologically based pharmacokinetic (PBPK) model for flutamide in rats and its extrapolation to humans. Environmental Research, 182, Article 108948. https://doi.org/10.1016/j.envres.2019.108948 [details]
- Westerhoff, H. V., & Kolodkin, A. N. (2020). Advice from a systems-biology model of the corona epidemics. Npj Systems Biology and Applications, 6, Article 18. https://doi.org/10.1038/s41540-020-0138-8 [details]
2019
- Colangelo, A. M., Cirillo, G., Alberghina, L., Papa, M., & Westerhoff, H. V. (2019). Neural plasticity and adult neurogenesis: the deep biology perspective. Neural Regeneration Research, 14(2), 201-205. https://doi.org/10.4103/1673-5374.244775 [details]
- Damiani, C., Maspero, D., Di Filippo, M., Colombo, R., Pescini, D., Graudenzi, A., Westerhoff, H. V., Alberghina, L., Vanoni, M., & Mauri, G. (2019). Integration of single-cell RNA-seq data into population models to characterize cancer metabolism. PLoS Computational Biology, 15(2), Article e1006733. https://doi.org/10.1371/journal.pcbi.1006733 [details]
- Hassan, Z., Sultana, M., Khan, S. I., Braster, M., Röling, W. F. M., & Westerhoff, H. V. (2019). Ample Arsenite Bio-Oxidation Activity in Bangladesh Drinking Water Wells: A Bonanza for Bioremediation? Microorganisms, 7(8), Article 246. https://doi.org/10.3390/microorganisms7080246 [details]
- Maeda, K., Westerhoff, H. V., Kurata, H., & Boogerd, F. C. (2019). Ranking network mechanisms by how they fit diverse experiments and deciding on E. coli's ammonium transport and assimilation network. Npj Systems Biology and Applications, 5, Article 14. https://doi.org/10.1038/s41540-019-0091-6 [details]
2018
- Abudukelimu, A., Barberis, M., Redegeld, F. A., Sahin, N., & Westerhoff, H. V. (2018). Predictable Irreversible Switching Between Acute and Chronic Inflammation. Frontiers in Immunology, 9, Article 1596. https://doi.org/10.3389/fimmu.2018.01596 [details]
- Swainston, N., Baici, A., Bakker, B. M., Cornish-Bowden, A., Fitzpatrick, P. F., Halling, P., Leyh, T. S., O'Donovan, C., Raushel, F. M., Reschel, U., Rohwer, J. M., Schnell, S., Schomburg, D., Tipton, K. F., Tsai, M-D., Westerhoff, H. V., Wittig, U., Wohlgemuth, R., & Kettner, C. (2018). STRENDA DB: enabling the validation and sharing of enzyme kinetics data. The FEBS Journal, 285(12), 2193-2204. https://doi.org/10.1111/febs.14427 [details]
- Węglarz-Tomczak, E., Talma, M., Giurg, M., Westerhoff, H. V., Janowski, R., & Mucha, A. (2018). Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs. Oncotarget, 9(50), 29365-29378. https://doi.org/10.18632/oncotarget.25532 [details]
2017
- Abudukelimu, A., Mondeel, T. D. G. A., Barberis, M., & Westerhoff, H. V. (2017). Learning to read and write in evolution: from static pseudoenzymes and pseudosignalers to dynamic gear shifters. Biochemical Society Transactions, 45(3), 635-652. https://doi.org/10.1042/BST20160281 [details]
- Damiani, C., Colombo, R., Gaglio, D., Mastroianni, F., Pescini, D., Westerhoff, H. W., Mauri, G., Vanoni, M., & Alberghina, L. (2017). A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect. PLoS Computational Biology, 13(9), Article e1005758. https://doi.org/10.1371/journal.pcbi.1005758 [details]
- Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J. H., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhütter, H-G., Szöör, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V., & Bakker, B. M. (2017). Targeting pathogen metabolism without collateral damage to the host. Scientific Reports, 7, Article 40406. https://doi.org/10.1038/srep40406 [details]
- Zhang, Y., Kouril, T., Snoep, J. L., Siebers, B., Barberis, M., & Westerhoff, H. V. (2017). The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico. International Journal of Molecular Sciences, 18(4), Article 876. https://doi.org/10.3390/ijms18040876 [details]
- van de Peppel, J., Strini, T., Tilburg, J., Westerhoff, H., van Wijnen, A. J., & van Leeuwen, J. P. (2017). Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics. Stem Cell Reports, 8(4), 947-960. https://doi.org/10.1016/j.stemcr.2017.02.018 [details]
2016
- Dols, J. A. M., Molenaar, D., van der Helm, J. J., Caspers, M. P. M., de Kat Angelino-Bart, A., Schuren, F. H. J., Speksnijder, A. G. C. L., Westerhoff, H. V., Richardus, J. H., Boon, M. E., Reid, G., de Vries, H. J. C., & Kort, R. (2016). Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity. BMC Infectious Diseases, 16, Article 180. https://doi.org/10.1186/s12879-016-1513-3 [details]
- He, F., Murabito, E., & Westerhoff, H. V. (2016). Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering. Journal of the Royal Society Interface, 13(117), Article 1046. https://doi.org/10.1098/rsif.2015.1046 [details]
- Wu, H., von Kamp, A., Leoncikas, V., Mori, W., Sahin, N., Gevorgyan, A., Linley, C., Grabowski, M., Mannan, A. A., Stoy, N., Stewart, G. R., Ward, L. T., Lewis, D. J. M., Sroka, J., Matsuno, H., Klamt, S., Westerhoff, H. V., McFadden, J., Plant, N. J., & Kierzek, A. M. (2016). MUFINS: multi-formalism interaction network simulator. Npj Systems Biology and Applications, 2, Article 16032. https://doi.org/10.1038/npjsba.2016.32 [details]
2015
- Lankelma, J., Kooi, B., Krab, K., Dorsman, J. C., Joenje, H., & Westerhoff, H. V. (2015). A reason for intermittent fasting to suppress the awakening of dormant breast tumors. Biosystems, 127, 1-6. https://doi.org/10.1016/j.biosystems.2014.11.001 [details]
- Rybakova, K. N., Bruggeman, F. J., Tomaszewska, A., Moné, M. J., Carlberg, C., & Westerhoff, H. V. (2015). Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism. PLoS Computational Biology, 11(4), e1004236. https://doi.org/10.1371/journal.pcbi.1004236 [details]
- Rybakova, K. N., Tomaszewska, A., van Mourik, S., Blom, J., Westerhoff, H. V., Carlberg, C., & Bruggeman, F. J. (2015). Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model. Nucleic Acids Research, 43(1), 153-161. Advance online publication. https://doi.org/10.1093/nar/gku1272 [details]
- Sellick, C. A., Croxford, A. S., Maqsood, A. R., Stephens, G. M., Westerhoff, H. V., Goodacre, R., & Dickson, A. J. (2015). Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness. Biotechnology Journal, 10(9), 1434-1445. https://doi.org/10.1002/biot.201400664 [details]
- Snoep, J. L., Green, K., Eicher, J., Palm, D. C., Penkler, G., du Toit, F., Walters, N., Burger, R., Westerhoff, H. V., & van Niekerk, D. D. (2015). Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients. Biochemical Society Transactions, 43(6), 1157-1163. https://doi.org/10.1042/BST20150145 [details]
- Westerhoff, H. V. (2015). Network-based pharmacology through systems biology. Drug Discovery Today. Technologies, 15, 15-16. https://doi.org/10.1016/j.ddtec.2015.05.001 [details]
- Westerhoff, H. V., Nakayama, S., Mondeel, T. D. G. A., & Barberis, M. (2015). Systems Pharmacology: An opinion on how to turn the impossible into grand challenges. Drug Discovery Today. Technologies, 15, 23-31. Advance online publication. https://doi.org/10.1016/j.ddtec.2015.06.006 [details]
- Wruck, W., Kashofer, K., Rehman, S., Daskalaki, A., Berg, D., Gralka, E., Jozefczuk, J., Drews, K., Pandey, V., Regenbrecht, C., Wierling, C., Turano, P., Korf, U., Zatloukal, K., Lehrach, H., Westerhoff, H. V., & Adjaye, J. (2015). Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. Scientific Data, 2, Article 150068. https://doi.org/10.1038/sdata.2015.68 [details]
2014
- Härdin, H. M., Zagaris, A., Willms, A. R., & Westerhoff, H. V. (2014). Clusters of reaction rates and concentrations in protein networks such as the phosphotransferase system. The FEBS Journal, 281(2), 531-548. Advance online publication. https://doi.org/10.1111/febs.12664 [details]
- Murabito, E., Verma, M., Bekker, M., Bellomo, D., Westerhoff, H. V., Teusink, B., & Steuer, R. (2014). Monte-Carlo modeling of the central carbon metabolism of Lactococcus lactis: insights into metabolic regulation. PLoS ONE, 9(9), Article e106453. https://doi.org/10.1371/journal.pone.0106453 [details]
- Ramírez-Bajo, M. J., de Atauri, P., Ortega, F., Westerhoff, H. V., Gelpí, J. L., Centelles, J. J., & Cascante, M. (2014). Effects of cadmium and mercury on the upper part of skeletal muscle glycolysis in mice. PLoS ONE, 9(1), Article e80018. https://doi.org/10.1371/journal.pone.0080018 [details]
- Westerhoff, H. V., Brooks, A. N., Simeonidis, E., García-Contreras, R., He, F., Boogerd, F. C., Jackson, V. J., Goncharuk, V., & Kolodkin, A. (2014). Macromolecular networks and intelligence in microorganisms. Frontiers in Microbiology, 5, Article 379. https://doi.org/10.3389/fmicb.2014.00379 [details]
2013
- Feldman-Salit, A., Hering, S., Messiha, H. L., Veith, N., Cojocaru, V., Sieg, A., Westerhoff, H. V., Kreikemeyer, B., Wade, R. C., & Fiedler, T. (2013). Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria. The Journal of Biological Chemistry, 288(29), 21295-21306. https://doi.org/10.1074/jbc.M113.458265 [details]
- Geenen, S., Yates, J. W. T., Kenna, J. G., Bois, F. Y., Wilson, I. D., & Westerhoff, H. V. (2013). Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats. Integrative Biology, 5(6), 877-888. Advance online publication. https://doi.org/10.1039/c3ib20245c [details]
- Geenen, S., du Preez, F. B., Snoep, J. L., Foster, A. J., Sarda, S., Kenna, J. G., Wilson, I. D., & Westerhoff, H. V. (2013). Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy. Biochimica et Biophysica Acta G General Subjects, 1830(10), 4943-59. Advance online publication. https://doi.org/10.1016/j.bbagen.2013.04.014 [details]
- He, F., Fromion, V., & Westerhoff, H. V. (2013). (Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis. BMC Systems Biology, 7, Article 131. https://doi.org/10.1186/1752-0509-7-131 [details]
- Kolodkin, A., Sahin, N., Phillips, A., Hood, S. R., Bruggeman, F. J., Westerhoff, H. V., & Plant, N. (2013). Optimization of stress response through the nuclear receptor-mediated cortisol signalling network. Nature Communications, 4, 1792. https://doi.org/10.1038/ncomms2799 [details]
- Kolodkin, A., Simeonidis, E., & Westerhoff, H. V. (2013). Computing life: add logos to biology and bios to physics. Progress in Biophysics & Molecular Biology, 111(2-3), 69-74. Advance online publication. https://doi.org/10.1016/j.pbiomolbio.2012.10.003 [details]
- Kouril, T., Esser, D., Kort, J., Westerhoff, H. V., Siebers, B., & Snoep, J. L. (2013). Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus. The FEBS Journal, 280(18), 4666-4680. Advance online publication. https://doi.org/10.1111/febs.12438 [details]
- Mensonides, F. I., Bakker, B. M., Cremazy, F., Messiha, H. L., Mendes, P., Boogerd, F. C., & Westerhoff, H. V. (2013). A new regulatory principle for in vivo biochemistry: pleiotropic low affinity regulation by the adenine nucleotides--illustrated for the glycolytic enzymes of Saccharomyces cerevisiae. FEBS Letters, 587(17), 2860-2867. https://doi.org/10.1016/j.febslet.2013.07.013 [details]
- Quinton-Tulloch, M. J., Bruggeman, F. J., Snoep, J. L., & Westerhoff, H. V. (2013). Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico. The FEBS Journal, 280(1), 160-173. Advance online publication. https://doi.org/10.1111/febs.12057 [details]
- Smallbone, K., Messiha, H. L., Carroll, K. M., Winder, C. L., Malys, N., Dunn, W. B., Murabito, E., Swainston, N., Dada, J. O., Khan, F., Pir, P., Simeonidis, E., Spasić, I., Wishart, J., Weichart, D., Hayes, N. W., Jameson, D., Broomhead, D. S., Oliver, S. G., ... Mendes, P. (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS Letters, 587(17), 2832-2841. https://doi.org/10.1016/j.febslet.2013.06.043 [details]
- Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., Haraldsdottir, H., Mo, M. L., Rolfsson, O., Stobbe, M. D., Thorleifsson, S. G., Agren, R., Bölling, C., Bordel, S., Chavali, A. K., Dobson, P., Dunn, W. B., Endler, L., Hala, D., ... Palsson, B. Ø. (2013). A community-driven global reconstruction of human metabolism. Nature Biotechnology, 31(5), 419-25. https://doi.org/10.1038/nbt.2488 [details]
- Verma, M., Karimiani, E. G., Byers, R. J., Rehman, S., Westerhoff, H. V., & Day, P. J. (2013). 555 mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies. Integrative Biology, 5(3), 543-554. Advance online publication. https://doi.org/10.1039/c3ib20230e [details]
- Verma, M., Zakhartsev, M., Reuss, M., & Westerhoff, H. V. (2013). 'Domino' systems biology and the 'A' of ATP. Biochimica et Biophysica Acta - Bioenergetics, 1827(1), 19-29. Advance online publication. https://doi.org/10.1016/j.bbabio.2012.09.014 [details]
- van Heeswijk, W. C., Westerhoff, H. V., & Boogerd, F. C. (2013). Nitrogen Assimilation in Escherichia coli: Putting Molecular Data into a Systems Perspective. Microbiology and Molecular Biology Reviews, 77(4), 628-695. https://doi.org/10.1128/MMBR.00025-13 [details]
2012
- Adamczyk, M., & Westerhoff, H. V. (2012). Engineering of self-sustaining systems: substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico. Biotechnology Journal, 7(7), 877-883. Advance online publication. https://doi.org/10.1002/biot.201100314 [details]
- García-Contreras, R., Vos, P., Westerhoff, H. V., & Boogerd, F. C. (2012). Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions. The FEBS Journal, 279(22), 4145-4159. Advance online publication. https://doi.org/10.1111/febs.12007 [details]
- Geenen, S., Taylor, P. N., Snoep, J. L., Wilson, I. D., Kenna, J. G., & Westerhoff, H. V. (2012). Systems biology tools for toxicology. Archives of toxicology = Archiv für Toxikologie, 86(8), 1251-1271. Advance online publication. https://doi.org/10.1007/s00204-012-0857-8 [details]
- Jozefczuk, J., Kashofer, K., Ummanni, R., Henjes, F., Rehman, S., Geenen, S., Wruck, W., Regenbrecht, C., Daskalaki, A., Wierling, C., Turano, P., Bertini, I., Korf, U., Zatloukal, K., Westerhoff, H. V., Lehrach, H., & Adjaye, J. (2012). A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells. Frontiers in Physiology, 3, 339. https://doi.org/10.3389/fphys.2012.00339 [details]
- Kolodkin, A., Simeonidis, E., Balling, R., & Westerhoff, H. V. (2012). Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence. Frontiers in Physiology, 3, 291. https://doi.org/10.3389/fphys.2012.00291 [details]
- Rehman, S., Day, P. J. R., Bayat, A., & Westerhoff, H. V. (2012). Understanding Dupuytren's disease using systems biology: a move away from reductionism. Frontiers in Physiology, 3, 316. https://doi.org/10.3389/fphys.2012.00316 [details]
- van Eunen, K., Kiewiet, J. A. L., Westerhoff, H. V., & Bakker, B. M. (2012). Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics. PLoS Computational Biology, 8(4), e1002483. https://doi.org/10.1371/journal.pcbi.1002483 [details]
2011
- Geenen, S., du Preez, F. B., Reed, M., Nijhout, H. F., Kenna, J. G., Wilson, I. D., Westerhoff, H. V., & Snoep, J. L. (2011). A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. European Journal of Pharmaceutical Sciences, 46(4), 233-243. https://doi.org/10.1016/j.ejps.2011.08.017 [details]
- Sellick, C. A., Croxford, A. S., Maqsood, A. R., Stephens, G., Westerhoff, H. V., Goodacre, R., & Dickson, A. J. (2011). Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production. Biotechnology and Bioengineering, 108(12), 3025-3031. https://doi.org/10.1002/bit.23269 [details]
2010
- van Eunen, K., Bouwman, J., Daran-Lapujade, P., Postmus, J., Canelas, A. B., Mensonides, F. I. C., Orij, R., Tuzun, I., van den Brink, J., Smits, G. J., van Gulik, W. M., Brul, S., Heijnen, J. J., de Winde, J. H., Teixeira De Mattos, M. J., Kettner, C., Nielsen, J., Westerhoff, H. V., & Bakker, B. M. (2010). Measuring enzyme activities under standardized in vivo-like conditions for systems biology. The FEBS Journal, 277(3), 749-760. https://doi.org/10.1111/j.1742-4658.2009.07524.x [details]
2009
- Härdin, H. M., Zagaris, A., Krab, K., & Westerhoff, H. V. (2009). Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations. The FEBS Journal, 276(19), 5491-5506. https://doi.org/10.1111/j.1742-4658.2009.07233.x [details]
2015
- Bastiaens, P., Birtwistle, M. R., Blüthgen, N., Bruggeman, F. J., Cho, K. H., Cosentino, C., de la Fuente, A., Hoek, J. B., Kiyatkin, A., Klamt, S., Kolch, W., Legewie, S., Mendes, P., Naka, T., Santra, T., Sontag, E., Westerhoff, H. V., & Kholodenko, B. N. (2015). Silence on the relevant literature and errors in implementation. Nature Biotechnology, 33(4), 336-339. https://doi.org/10.1038/nbt.3185 [details]
2017
- Kempe, H. (2017). Understanding gene expression variability in its biological context using theoretical and experimental analyses of single cells. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Lauss, K. (2017). Phenotypic variation in plants: Roles for epigenetics. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2017
- van Wijnen, A. J., van de Peppel, J., Westerhoff, H., van Leeuwen, J. P., Strini, T. & Tilburg, J. (2017). Gene expression analyses of the differentiating hMSC into Osteoblasts and Adipocytes.. Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80614
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list. -
Nevenwerkzaamheden
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University of Manchester, SCEAS
Hoogleraar
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University of Manchester, SCEAS
Bruggeman, F. J., Remeijer, M., Droste, M., Salinas, L., Wortel, M., Planqué, R., Sauro, H. M., Teusink, B., & Westerhoff, H. V. (2023). Whole-cell metabolic control analysis. Biosystems, 234, Article 105067.