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Dr. C.J. (Caitrín) Crudden PhD

Universitair Docent
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
  • Science Park 904
  • Kamernummer: C2.103
Postadres
Contactgegevens
  • Publicaties

    2024

    • Di Niro, L., Linders, A. C., Glynn, T., Pegtel, D. M., Siderius, M., Crudden, C., & Smit, M. J. (2024). G protein-coupled receptors: a gateway to targeting oncogenic EVs? Extracellular Vesicles and Circulating Nucleic Acids, 5(2), 233-248. https://doi.org/10.20517/evcna.2024.10

    2023

    • Bebelman, M. P., Setiawan, I. M., Bergkamp, N. D., van Senten, J. R., Crudden, C., Bebelman, J. P. M., Verweij, F. J., van Niel, G., Siderius, M., Pegtel, D. M., & Smit, M. J. (2023). Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging. iScience, 26(8), Article 107412. https://doi.org/10.1016/j.isci.2023.107412
    • Cismas, S., Pasca, S., Crudden, C., Trocoli Drakensjo, I., Suleymanova, N., Zhang, S., Gebhard, B., Song, D., Neo, S., Shibano, T., Smith, T. J., Calin, G. A., Girnita, A., & Girnita, L. (2023). Competing Engagement of β-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness. Molecular Cancer Research, 21(12), 1288-1302. https://doi.org/10.1158/1541-7786.MCR-22-0871
    • Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2023). Correction: IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 42(11), 858. https://doi.org/10.1038/s41388-023-02607-8

    2022

    • Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2022). IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 41(4), 600-611. https://doi.org/10.1038/s41388-021-02111-x

    2021

    • Bebelman, M. P., Janssen, E., Pegtel, D. M., & Crudden, C. (2021). The forces driving cancer extracellular vesicle secretion. Neoplasia, 23(1), 149-157. https://doi.org/10.1016/j.neo.2020.11.011
    • Crudden, C., Shibano, T., Song, D., Dragomir, M. P., Cismas, S., Serly, J., Nedelcu, D., Fuentes-Mattei, E., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2021). Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. Cancer Research, 81(2), 501-514. https://doi.org/10.1158/0008-5472.CAN-20-1662

    2020

    2019

    • Crudden, C., Song, D., Cismas, S., Trocmé, E., Pasca, S., Calin, G. A., Girnita, A., & Girnita, L. (2019). Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey. Cells, 8(10). https://doi.org/10.3390/cells8101223

    2018

    • Crudden, C., Shibano, T., Song, D., Suleymanova, N., Girnita, A., & Girnita, L. (2018). Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors. International review of cell and molecular biology, 339, 1-40. https://doi.org/10.1016/bs.ircmb.2018.02.006
    • Lohcharoenkal, W., Das Mahapatra, K., Pasquali, L., Crudden, C., Kular, L., Akkaya Ulum, Y. Z., Zhang, L., Xu Landén, N., Girnita, L., Jagodic, M., Ståhle, M., Sonkoly, E., & Pivarcsi, A. (2018). Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. Journal of Investigative Dermatology, 138(4), 882-892. https://doi.org/10.1016/j.jid.2017.09.049

    2017

    • Suleymanova, N., Crudden, C., Shibano, T., Worrall, C., Oprea, I., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2017). Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene, 36(41), 5734-5744. https://doi.org/10.1038/onc.2017.179
    • Suleymanova, N., Crudden, C., Worrall, C., Dricu, A., Girnita, A., & Girnita, L. (2017). Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation. Oncotarget, 8(47), 82256-82267. https://doi.org/10.18632/oncotarget.19286
    • Worrall, C., Suleymanova, N., Crudden, C., Trocoli Drakensjö, I., Candrea, E., Nedelcu, D., Takahashi, S. I., Girnita, L., & Girnita, A. (2017). Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene, 36(23), 3274-3286. https://doi.org/10.1038/onc.2016.472

    2016

    • Girnita, L., Girnita, A., & Crudden, C. (2016). Differential Regulation of IGF-1 and Insulin Signaling by GRKs. In Methods in Pharmacology and Toxicology (pp. 151-171). (Methods in Pharmacology and Toxicology). Humana Press Inc., 2007. https://doi.org/10.1007/978-1-4939-3798-1_7
    • Girnita, L., Takahashi, S. I., Crudden, C., Fukushima, T., Worrall, C., Furuta, H., Yoshihara, H., Hakuno, F., & Girnita, A. (2016). Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling. In S. K. Shenoy (Ed.), Ubiquitination and Transmembrane Signaling (pp. 277-311). (Progress in Molecular Biology and Translational Science; Vol. 141). Elsevier B.V. https://doi.org/10.1016/bs.pmbts.2016.04.001

    2015

    • Crudden, C., Girnita, A., & Girnita, L. (2015). Targeting the IGF-1R: The Tale of the Tortoise and the Hare. Frontiers in Endocrinology, 6, 64. https://doi.org/10.3389/fendo.2015.00064
    • Crudden, C., Ilic, M., Suleymanova, N., Worrall, C., Girnita, A., & Girnita, L. (2015). The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment? Growth Hormone & IGF Research, 25(1), 2-12. https://doi.org/10.1016/j.ghir.2014.10.002

    Prijs / subsidie

    • Crudden, C. (2022). ZonMw Off-Road Grant.
    • Crudden, C. (2021). ZonMw Veni Fellowship; 09150162010212.
    • Crudden, C. (2018). Marie Skłodowska-Curie Fellowship; 845391.
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
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