Dr. C.J. (Caitrín) Crudden PhD

Universitair Docent

Faculteit der Natuurwetenschappen, Wiskunde en Informatica

Swammerdam Institute for Life Sciences

Bezoekadres

Science Park 904
Kamernummer: C2.103

Postadres

Contactgegevens

Publicaties
- refereed (19)
- erkenning (3)
2024

Di Niro, L., Linders, A. C., Glynn, T., Pegtel, D. M., Siderius, M., Crudden, C., & Smit, M. J. (2024). G protein-coupled receptors: a gateway to targeting oncogenic EVs? Extracellular Vesicles and Circulating Nucleic Acids, 5(2), 233-248. https://doi.org/10.20517/evcna.2024.10
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2023

Bebelman, M. P., Setiawan, I. M., Bergkamp, N. D., van Senten, J. R., Crudden, C., Bebelman, J. P. M., Verweij, F. J., van Niel, G., Siderius, M., Pegtel, D. M., & Smit, M. J. (2023). Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging. iScience, 26(8), Article 107412. https://doi.org/10.1016/j.isci.2023.107412

Cismas, S., Pasca, S., Crudden, C., Trocoli Drakensjo, I., Suleymanova, N., Zhang, S., Gebhard, B., Song, D., Neo, S., Shibano, T., Smith, T. J., Calin, G. A., Girnita, A., & Girnita, L. (2023). Competing Engagement of β-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness. Molecular Cancer Research, 21(12), 1288-1302. https://doi.org/10.1158/1541-7786.MCR-22-0871

Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2023). Correction: IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 42(11), 858. https://doi.org/10.1038/s41388-023-02607-8

2022

Song, D., Cismas, S., Crudden, C., Trocme, E., Worrall, C., Suleymanova, N., Lin, T., Zheng, H., Seregard, S., Girnita, A., & Girnita, L. (2022). IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma. Oncogene, 41(4), 600-611. https://doi.org/10.1038/s41388-021-02111-x

2021

Bebelman, M. P., Janssen, E., Pegtel, D. M., & Crudden, C. (2021). The forces driving cancer extracellular vesicle secretion. Neoplasia, 23(1), 149-157. https://doi.org/10.1016/j.neo.2020.11.011

Crudden, C., Shibano, T., Song, D., Dragomir, M. P., Cismas, S., Serly, J., Nedelcu, D., Fuentes-Mattei, E., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2021). Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. Cancer Research, 81(2), 501-514. https://doi.org/10.1158/0008-5472.CAN-20-1662

2020

Bebelman, M. P., Crudden, C., Pegtel, D. M., & Smit, M. J. (2020). The Convergence of Extracellular Vesicle and GPCR Biology. Trends in pharmacological sciences, 41(9), 627-640. https://doi.org/10.1016/j.tips.2020.07.001

Crudden, C., & Girnita, L. (2020). The tale of a tail: The secret behind IGF-1R's oncogenic power. Science Signaling, 13(633). https://doi.org/10.1126/scisignal.abb7887

2019

Crudden, C., Song, D., Cismas, S., Trocmé, E., Pasca, S., Calin, G. A., Girnita, A., & Girnita, L. (2019). Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey. Cells, 8(10). https://doi.org/10.3390/cells8101223

2018

Crudden, C., Shibano, T., Song, D., Suleymanova, N., Girnita, A., & Girnita, L. (2018). Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors. International review of cell and molecular biology, 339, 1-40. https://doi.org/10.1016/bs.ircmb.2018.02.006

Lohcharoenkal, W., Das Mahapatra, K., Pasquali, L., Crudden, C., Kular, L., Akkaya Ulum, Y. Z., Zhang, L., Xu Landén, N., Girnita, L., Jagodic, M., Ståhle, M., Sonkoly, E., & Pivarcsi, A. (2018). Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. Journal of Investigative Dermatology, 138(4), 882-892. https://doi.org/10.1016/j.jid.2017.09.049

2017

Suleymanova, N., Crudden, C., Shibano, T., Worrall, C., Oprea, I., Tica, A., Calin, G. A., Girnita, A., & Girnita, L. (2017). Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene, 36(41), 5734-5744. https://doi.org/10.1038/onc.2017.179

Suleymanova, N., Crudden, C., Worrall, C., Dricu, A., Girnita, A., & Girnita, L. (2017). Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation. Oncotarget, 8(47), 82256-82267. https://doi.org/10.18632/oncotarget.19286

Worrall, C., Suleymanova, N., Crudden, C., Trocoli Drakensjö, I., Candrea, E., Nedelcu, D., Takahashi, S. I., Girnita, L., & Girnita, A. (2017). Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene, 36(23), 3274-3286. https://doi.org/10.1038/onc.2016.472

2016

Girnita, L., Girnita, A., & Crudden, C. (2016). Differential Regulation of IGF-1 and Insulin Signaling by GRKs. In G Protein-Coupled Receptor Kinases (pp. 151-171). (Methods in Pharmacology and Toxicology). Humana Press. https://doi.org/10.1007/978-1-4939-3798-1_7

Girnita, L., Takahashi, S. I., Crudden, C., Fukushima, T., Worrall, C., Furuta, H., Yoshihara, H., Hakuno, F., & Girnita, A. (2016). Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling. In S. K. Shenoy (Ed.), Ubiquitination and Transmembrane Signaling (pp. 277-311). (Progress in Molecular Biology and Translational Science; Vol. 141). Elsevier B.V. https://doi.org/10.1016/bs.pmbts.2016.04.001

2015

Crudden, C., Girnita, A., & Girnita, L. (2015). Targeting the IGF-1R: The Tale of the Tortoise and the Hare. Frontiers in Endocrinology, 6, 64. https://doi.org/10.3389/fendo.2015.00064

Crudden, C., Ilic, M., Suleymanova, N., Worrall, C., Girnita, A., & Girnita, L. (2015). The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment? Growth Hormone & IGF Research, 25(1), 2-12. https://doi.org/10.1016/j.ghir.2014.10.002
Prijs / subsidie

Crudden, C. (2022). ZonMw Off-Road Grant.

Crudden, C. (2021). ZonMw Veni Fellowship; 09150162010212.

Crudden, C. (2018). Marie Skłodowska-Curie Fellowship; 845391.
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Dr. C.J. (Caitrín) Crudden PhD

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