Chair of BioNanoPhotonics
also:
On-going projects:
Research activities are funded by:
Specially confined systems, including nanosystems, are at the forefront of functional material science. The objective of our research is to investigate and design functional molecules and nanostructures with special optical properties which might lead to applications in, among others, biomedical field. The study is motivated by the scientific challenge it poses to physics and chemistry when the size of a system approaches nanometer scale.
One of our research themes is the intra- and intermolecular interactions and their interplay in condensed phases under different conditions, for example size confinement, extremely high viscosity, biological surroundings, among which processes like charge generation/recombination, electron transfer, proton transfer, isomerization and conformational changes, solvent reorganization, vibrationalrelaxation (vibrational cooling), often occur (see left figure, Chem. Rev. 2004). The physical and chemical properties of the emitting elements at initial stage upon external stimuli, play a central role in our research.
Our lab is facilitated with femtosecond fluorescence upconversion setup, picosecond time-correlated single-photon-counting setup, confocal microscope and other time-resolved and steady-state spectroscopic facilities. The powerful spectroscopic techniques enable us to monitor, in real time and in whole time range, the excited state dynamics of noble metals, quantum dots and discrete emissive centers, where the effect can be recovered of surface properties and quantum confinement of electron and/or hole to the photo-excitation and de-excitation dynamics (Angw. Chem. Int. Ed. 2023, Nature Nanotechnology 2010).
Our another research theme is to develop novel photonic nanoplatforms for biomedical applications. Typical example is the luminescence upconversion nanoplatform, where the discrete emissive centers - lanthanide ions - are embedded in a nanohost, and efficient IR- to Vis/UV photon upconversion is realized (see right figure). Different structured, biofunctionalized upconversion nanosystems have been developed in our lab with high upconversion luminescence and photostability, based on the fully spectroscopic study and theoretical modelling of their photophysics and photochemistry. It has been demonstrated that this system is superior in penetration and is applicable for the diagnosis and therapy of cancer cells and bacterials ( Chem. Soc. Rev. 2015 ; ACS NANO 2012 , Angw. Chem. Int. Ed. 2018).
Postal address :
van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam,
P.O. Box 94157, 1090 GD Amsterdam
Visiting address:Office: C2253, Science Park 904, 1098 XH Amsterdam
Phone: (office) +31-20-525 6976
E-mail: h.zhang@uva.nl
Url: https://www.uva.nl/en/profile/z/h/h.zhang/h.zhang.html
Kefan Wu, Enhui Wang, Jun Yuan, Jing Zuo, Ding Zhou, Haifeng Zhao, Yongshi Luo, Ligong Zhang, Bin Li, Jiahua, Zhang, Langping Tu, and Hong Zhang
Cross Relaxation Channel Tailored Temperature Response in Er3+-rich Upconversion Nanophosphor
Angew. Chem. Int. Ed. 62 (2023) e202306585.
Yuxin Liu, Zheng Wei, Matteo Damian, Xingjun Zhu, Tanja Knaus, Hong Zhang, Francesco G. Mutti, Felix F. Loeffler
Recyclable and robust optical nanoprobes with engineered enzymes for sustainable serodiagnostics
Adv. Mater. 35 (2023) 2306615.
Langping Tu, Xiaomin Liu, Fei Wu, Hong Zhang
Excitation Energy Migration Dynamics in Upconversion Nanomaterials
Chem. Soc. Rev. 44 (6) (2015) 1331 - 1345.
Wieteke De Boer, Dolf Timmerman, Katerina Dohnalova, Irina Yassievich, Hong Zhang, Wybren Jan Buma, Tom Gregorkiewicz
Red spectral shift and enhanced quantum efficiency of no-phonon emission from silicon nanocrystals
Nature Nanotechnology 5(12) (2010) 827-828.
M. Glasbeek and H. Zhang,
Femtosecond studies of solvation and intramolecular configuration dynamics of fluorophores in liquid solution,
Chem. Rev. 104 (2004) 1929-1954.
J. Zuo, D. P. Sun, L. P. Tu, Y. N. Wu, Y. H. Cao, B. Xue, Y. L. Zhang, Y. L. Chang, X. M. Liu, X. G. Kong, W. J. Buma, E. J. Meijer, H. Zhang
Precisely tailoring upconversion dynamics via energy migration in core-shell nanostructures
Angew. Chem. Int. Ed. 57 (2018) 3054-3058 DOI: 10.1002/anie.201711606 and 10.1002/ange.201711606 (cover story).
Kai Liu, Xiaomin Liu, Qinghui Zeng, Youlin Zhang, Langping Tu, Tao Liu, Xianggui Kong, Yinghui Wang, Feng Cao, Saskia A.G. Lambrechts, Maurice C.G. Aalders, and Hong Zhang
Covalently assembled NIR nanoplatform for simultaneous fluorescence imaging and photodynamic therapy of cancer cells,
ACS Nano 6 (5) (2012) 4054 - 4062.
Qing Lou, Songnan Qu, Pengtao Jing, Wenyu Ji, Di Li, Junsheng Cao, Hong Zhang, Lei Liu, Jialong Zhao, Dezhen Shen
Water-triggered luminescent “nano-bombs” based on supra-(carbon nanodots)
Adv. Maters. 27 (8) (2015) 1389-1394.
Yajuan Sun, Hongjian Liu, Xin Wang, Xianggui Kong, and Hong Zhang,
Optical spectroscopy and visible upconversion studies of YVO4:Er3+ nanoparticles synthesized by a hydrothermal process,
Chem. Mater. 18 (2006) 2726.
E. Hendry, M. Koeberg, F. Wang, H. Zhang, C. de Mello Donega, D. Vanmaekelbergh and M. Bonn,
Direct observation of electron to hole energy transfer in CdSe quantum dots,
Phys. Rev. Lett. 96 (2006) 057408.
L. Brunsveld, H. Zhang, M. Glasbeek, J.A.J.M. Vekemans, and E.W. Meijer,
Hierarchical growth of chiral self-assembled structures in polar media,
J. Am. Chem. Soc. 122 (2000) 6175.
L.P. Tu, H. Zhang
Chapter 4: Upconversion luminescence of nanophosphors: mechanisms and properties. Phosphor Handbook (eds. R.S. Liu, X.J. Wang, CRC Press), ISBN 9780367555146, 2022.
X.M. Liu, H. Zhang
Chapter 16: New Generation of Photosensitizers Based on Inorganic Nanomaterials. Photodynamic Therapy - Methods and Protocols. (Methods in Molecular Biology series, vol. 2451, eds. M. Broekgaarden, H. Zhang, M. Korbelik, M. R. Hamblin, M. Heger, Humana Press Inc.), ISBN 1064-3745, 2022.
H. Zhang, L.P. Tu, X.M. Liu,
Chapter 2: Principle of luminescence upconversion and its enhancement in nanosystems,
Upconverting Nanomaterials: Perspectives, Synthesis, and Applications (eds. C. Altavilla, 2016, CRC press, Taylor & Francis group), ISBN 9781498707749, 2016.
Undergraduate and Graduate Courses