Dr. J.C. (Hans) van der Spek
- Science Park 904
- Room number: C3.262
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Postbus 94232
1090 GE Amsterdam
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Profile
General information
I am assistant professor in the group 'Molecular Biology and Microbial Food Safety' headed by Prof Stanley Brul at the Swammerdam Institute for Life Sciences (SILS) at the University of Amsterdam (UvA). For a general description of the research interests of the group refer to:
Personal research interest
My personal research interest is on mitochondrial genetics and function (yeast, man, nematodes), including topics like regulation of translation, respiratory complex assembly and regulation of transcription (mainly in bakers yeast). Recently the focus has shifted to anti-retroviral drug-induced mitochondrial dysfunction that has become apparent in HIV-1 infected patients (see below). To address fundamental questions concerning mitochondrial (dys)function the nematode Caenorhabditis elegans has been introduced in the lab and employed as a model organism. For an overview of recent results follow the link to see the poster presented at the SILS researchday in January 2008.
Additional research activities are supervision of fundamental and applied research projects concerning food spoilage microorganisms such as Bacillus subtilis .Student Projects
Within our 'mitochondrial (dys)function' group (staff, PhD student and a technician) there are possibilities for Bachelor-, Master- and HBO students to perform a research project. For a general description of the research project follow the link. For more information contact Hans van der Spek.
Publications
Follow the link to see the publications.
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Publications
2017
Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S., & van der Spek, H. (2017). Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity. PLoS ONE, 12(11), Article e0187424. https://doi.org/10.1371/journal.pone.0187424 [details]
2015
- Smith, R. L., De Vos, W. H., de Boer, R., Manders, E. M. M., & van der Spek, H. (2015). In vivo visualization and quantification of mitochondrial morphology in C. elegans. In V. Weissig, & M. Edeas (Eds.), Mitochondrial medicine. - Vol. 2: Manipulating mitochondrial function (pp. 367-377). (Methods in molecular biology; No. 1265). Humana Press. https://doi.org/10.1007/978-1-4939-2288-8_26 [details]
- de Boer, R., Smith, R. L., De Vos, W. H., Manders, E. M. M., Brul, S., & van der Spek, H. (2015). Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity. PLoS ONE, 10(5), Article e0126220. https://doi.org/10.1371/journal.pone.0126220 [details]
2013
- Smith, R. L., de Boer, R., Brul, S., Budovskaya, Y., & van der Spek, H. (2013). Premature and accelerated aging: HIV or HAART? Frontiers in Genetics, 3, 328. https://doi.org/10.3389/fgene.2012.00328 [details]
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list. -
Ancillary activities
- No ancillary activities
Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S., & van der Spek, H. (2017). Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity. PLoS ONE, 12(11), Article e0187424.