Dr. J.C. (Hans) van der Spek

Faculty of Science

Swammerdam Institute for Life Sciences

Photographer: onbekend

Visiting address

Science Park 904
Room number: C3.262

Postal address

Postbus 94232
1090 GE Amsterdam

Contact details

Profile

General information

I am assistant professor in the group 'Molecular Biology and Microbial Food Safety' headed by Prof Stanley Brul at the Swammerdam Institute for Life Sciences (SILS) at the University of Amsterdam (UvA). For a general description of the research interests of the group refer to:

The group: SILS/MB&MFS

Staff: Prof. dr Stanley Brul

Staff: dr Gertien Smits

Personal research interest

My personal research interest is on mitochondrial genetics and function (yeast, man, nematodes), including topics like regulation of translation, respiratory complex assembly and regulation of transcription (mainly in bakers yeast). Recently the focus has shifted to anti-retroviral drug-induced mitochondrial dysfunction that has become apparent in HIV-1 infected patients (see below). To address fundamental questions concerning mitochondrial (dys)function the nematode Caenorhabditis elegans has been introduced in the lab and employed as a model organism. For an overview of recent results follow the link to see the poster presented at the SILS researchday in January 2008.
Additional research activities are supervision of fundamental and applied research projects concerning food spoilage microorganisms such as Bacillus subtilis .

Poster recentresults

Student Projects

Within our 'mitochondrial (dys)function' group (staff, PhD student and a technician) there are possibilities for Bachelor-, Master- and HBO students to perform a research project. For a general description of the research project follow the link. For more information contact Hans van der Spek.

Student Project

Publications

Follow the link to see the publications.

Publications via DARE (not complete)
Publications
- refereed (4)
2017

Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S., & van der Spek, H. (2017). Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity. PLoS ONE, 12(11), Article e0187424. https://doi.org/10.1371/journal.pone.0187424 [details]
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2015

Smith, R. L., De Vos, W. H., de Boer, R., Manders, E. M. M., & van der Spek, H. (2015). In vivo visualization and quantification of mitochondrial morphology in C. elegans. In V. Weissig, & M. Edeas (Eds.), Mitochondrial medicine. - Vol. 2: Manipulating mitochondrial function (pp. 367-377). (Methods in molecular biology; No. 1265). Humana Press. https://doi.org/10.1007/978-1-4939-2288-8_26 [details]

de Boer, R., Smith, R. L., De Vos, W. H., Manders, E. M. M., Brul, S., & van der Spek, H. (2015). Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity. PLoS ONE, 10(5), Article e0126220. https://doi.org/10.1371/journal.pone.0126220 [details]
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Caenorhabditis elegans
journal.pone.0126220.s001
journal.pone.0126220.s002
journal.pone.0126220.s003

2013

Smith, R. L., de Boer, R., Brul, S., Budovskaya, Y., & van der Spek, H. (2013). Premature and accelerated aging: HIV or HAART? Frontiers in Genetics, 3, 328. https://doi.org/10.3389/fgene.2012.00328 [details]
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Ancillary activities
- No ancillary activities

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Dr. J.C. (Hans) van der Spek

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