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Dr. J.E. (Jurgen) Seppen

Faculty of Science
Graduate School of Life and Earth Sciences
Visiting address
  • Science Park 904
Postal address
  • Postbus 94214
    1090 GE Amsterdam
Contact details
  • Publications

    2022

    2021

    • Koopman, N., Katsavelis, D., Ten Hove, A. S., Brul, S., de Jonge, W. J., & Seppen, J. (2021). The multifaceted role of serotonin in intestinal homeostasis. International Journal of Molecular Sciences, 22(17), Article 9487. https://doi.org/10.3390/ijms22179487 [details]
    • Ten Hove, A. S., Seppen, J., & de Jonge, W. J. (2021). Neuronal innervation of the intestinal crypt. American Journal of Physiology - Gastrointestinal and Liver Physiology, 320(2), G193-G205. https://doi.org/10.1152/AJPGI.00239.2020

    2020

    • Diederen, K., Li, J. V., Donachie, G. E., de Meij, T. G., de Waart, D. R., Hakvoort, T. B. M., Kindermann, A., Wagner, J., Auyeung, V., te Velde, A. A., Heinsbroek, S. E. M., Benninga, M. A., Kinross, J., Walker, A. W., de Jonge, W. J., & Seppen, J. (2020). Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease. Scientific Reports, 10(1), Article 18879. https://doi.org/10.1038/s41598-020-75306-z
    • van Thiel, I. A. M., Botschuijver, S., de Jonge, W. J., & Seppen, J. (2020). Painful interactions: Microbial compounds and visceral pain. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866(1), Article 165534. https://doi.org/10.1016/j.bbadis.2019.165534

    2019

    • Végh, A. M. D., Dénise den Haan, A., Ortega, L. C., Verkerk, A. O., Sluijter, J. P. G., Bakker, D., Van Amersfoorth, S., Van Veen, T. A. B., Klerk, M., Seppen, J., De Bakker, J. M. T., Christoffels, V. M., Geerts, D., Goumans, M. J. T. H., Tan, H. L., & Boink, G. J. J. (2019). Cardiomyocyte progenitor cells as a functional gene delivery vehicle for long-term biological pacing. Molecules, 24(1), Article 181. https://doi.org/10.3390/molecules24010181
    • Willemze, R. A., Brinkman, D. J., Welting, O., Van Hamersveld, P. H. P., Verseijden, C., Luyer, M. D., Wildenberg, M. E., Seppen, J., & de Jonge, W. J. (2019). Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 317(5), G557-G568. https://doi.org/10.1152/AJPGI.00067.2019
    • Willemze, R. A., Welting, O., van Hamersveld, P., Verseijden, C., Nijhuis, L. E., Hilbers, F. W., Meijer, S. L., Heesters, B. A., Folgering, J. H. A., Darwinkel, H., Blancou, P., Vervoordeldonk, M. J., Seppen, J., Heinsbroek, S. E. M., & de Jonge, W. J. (2019). Loss of intestinal sympathetic innervation elicits an innate immune driven colitis. Molecular Medicine, 25(1), Article 1. https://doi.org/10.1186/s10020-018-0068-8

    2018

    • Botschuijver, S., Welting, O., Levin, E., Maria-Ferreira, D., Koch, E., Montijn, R. C., Seppen, J., Hakvoort, T. B. M., Schuren, F. H. J., de Jonge, W. J., & van den Wijngaard, R. M. (2018). Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation. Neurogastroenterology and motility, 30(6), Article e13299. https://doi.org/10.1111/nmo.13299
    • Willemze, R. A., Welting, O., van Hamersveld, H. P., Meijer, S. L., Folgering, J. H. A., Darwinkel, H., Witherington, J., Sridhar, A., Vervoordeldonk, M. J., Seppen, J., & de Jonge, W. J. (2018). Neuronal control of experimental colitis occurs via sympathetic intestinal innervation. Neurogastroenterology and motility, 30(3), Article e13163. https://doi.org/10.1111/nmo.13163

    2017

    • Botschuijver, S., Roeselers, G., Levin, E., Jonkers, D. M., Welting, O., Heinsbroek, S., de Weerd, H. H., Boekhout, T., Fornai, M., Masclee, A. A., Schuren, F. H. J., de Jonge, W. J., Seppen, J., & van den Wijngaard, R. M. (2017). Intestinal Fungal Dysbiosis Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats. Gastroenterology, 153(4), 1026-1039. Advance online publication. https://doi.org/10.1053/j.gastro.2017.06.004 [details]
    • Van Dijk, R., Aronson, S. J., De Waart, D. R., Van De Graaf, S. F., Duijst, S., Seppen, J., Elferink, R. O., Beuers, U., & Bosma, P. J. (2017). Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo. Scientific Reports, 7(1), Article 1646. https://doi.org/10.1038/s41598-017-01602-w

    2016

    • Dhawan, S., de Palma, G., Willemze, R. A., Hilbers, F. W., Verseijden, C., Luyer, M. D., Nuding, S., Wehkamp, J., Souwer, Y., de Jong, E. C., Seppen, J., van den Wijngaard, R. M., Wehner, S., Verdu, E., Bercik, P., & de Jonge, W. J. (2016). Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311(5), G920-G933. https://doi.org/10.1152/ajpgi.00114.2016
    • Schilderink, R., Verseijden, C., Seppen, J., Muncan, V., van den Brink, G. R., Lambers, T. T., van Tol, E. A., & de Jonge, W. J. (2016). The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310(11), G1138-G1146. https://doi.org/10.1152/ajpgi.00411.2015

    2015

    • Kingma, S. D. K., Wagemans, T., IJlst, L., Seppen, J., Gijbels, M. J. J., Wijburg, F. A., & van Vlies, N. (2015). Adverse effects of genistein in a mucopolysaccharidosis type I mouse model. JIMD Reports, 23, 77-83. https://doi.org/10.1007/8904_2015_432

    2014

    • El Filali, E., Duijst, S., Hiralall, J. K., Legrand, N., van Gulik, T., Hoekstra, R., & Seppen, J. (2014). Human fetal liver cells for regulated ex vivo erythropoietin gene therapy. Molecular Therapy - Methods and Clinical Development, 1, 14003. https://doi.org/10.1038/mtm.2014.3
    • Van Wenum, M., Chamuleau, R. A., Van Gulik, T. M., Siliakus, A., Seppen, J., & Hoekstra, R. (2014). Bioartificial livers in vitro and in vivo: Tailoring biocomponents to the expanding variety of applications. Expert Opinion on Biological Therapy, 14(12), 1745-1760. https://doi.org/10.1517/14712598.2014.950651

    2013

    • Abel, T., Filali, E. E., Waern, J., Schneider, I. C., Yuan, Q., Münch, R. C., Hick, M., Warnecke, G., Madrahimov, N., Kontermann, R. E., Schuttrumpf, J., Müller, U. C., Seppen, J., Ott, M., & Buchholz, C. J. (2013). Specific gene delivery to liver sinusoidal & artery endothelial cells. Blood, 122(12), 2030-2038. https://doi.org/10.1182/blood-2012-11-468579
    • Filali, E. E., Hiralall, J. K., van Veen, H. A., Stolz, D. B., & Seppen, J. (2013). Human liver endothelial cells, but not macrovascular or microvascular endothelial cells, engraft in the mouse liver. Cell transplantation, 22(10), 1801-1811. https://doi.org/10.3727/096368912X657594
    • Hoekstra, R., Nibourg, G. A. A., Van Der Hoeven, T. V., Plomer, G., Seppen, J., Ackermans, M. T., Camus, S., Kulik, W., Van Gulik, T. M., Oude Elferink, R. P., & Chamuleau, R. A. F. M. (2013). Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide. Drug Metabolism and Disposition, 41(3), 562-567. https://doi.org/10.1124/dmd.112.049098
    • Seppen, J., & Bruzzone, L. (2013). Lynch syndrome: The patients perspective. Familial Cancer, 12(2), 341-345. https://doi.org/10.1007/s10689-013-9630-2

    2012

    • Bakker, M. L., Boink, G. J. J., Boukens, B. J., Verkerk, A. O., Van Den Boogaard, M., Den Haan, A. D., Hoogaars, W. M. H., Buermans, H. P., De Bakker, J. M. T., Seppen, J., Tan, H. L., Moorman, A. F. M., T Hoen, P. A. C., & Christoffels, V. M. (2012). T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. Cardiovascular research, 94(3), 439-449. https://doi.org/10.1093/cvr/cvs120
    • Falix, F. A., Aronson, D. C., Lamers, W. H., Hiralall, J. K., & Seppen, J. (2012). DLK1, a serum marker for hepatoblastoma in young infants. Pediatric Blood and Cancer, 59(4), 743-745. https://doi.org/10.1002/pbc.24024
    • Folmer, D. E., Mok, K. S., de Wee, S. W., Duijst, S., Hiralall, J. K., Seppen, J., Oude Elferink, R. P. J., & Paulusma, C. C. (2012). Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated β-subunit for P4 ATPases. Journal of Histochemistry and Cytochemistry, 60(3), 205-218. https://doi.org/10.1369/0022155411435705
    • Seppen, J. (2012). A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase. Toxicology and Applied Pharmacology, 264(3), 335-342. https://doi.org/10.1016/j.taap.2012.09.013
    • Seppen, J., & Bosma, P. (2012). Bilirubin, the gold within. Circulation, 126(22), 2547-2549. https://doi.org/10.1161/CIRCULATIONAHA.112.147082

    2011

    • Groen, A., Romero, M. R., Kunne, C., Hoosdally, S. J., Dixon, P. H., Wooding, C., Williamson, C., Seppen, J., Van Den Oever, K., Mok, K. S., Paulusma, C. C., Linton, K. J., & Oude Elferink, R. P. J. (2011). Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology, 141(5), 1927-1937.e4. https://doi.org/10.1053/j.gastro.2011.07.042

    2010

    • Centlivre, M., Zhou, X., Pouw, S. M., Weijer, K., Kleibeuker, W., Das, A. T., Blom, B., Seppen, J., Berkhout, B., & Legrand, N. (2010). Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo. Gene Therapy, 17(1), 14-25. https://doi.org/10.1038/gt.2009.109
    • Markusic, D. M., de Waart, D. R., & Seppen, J. (2010). Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats. PLoS ONE, 5(4), e9974. https://doi.org/10.1371/journal.pone.0009974 [details]
    • Markusic, D., & Seppen, J. (2010). Doxycycline regulated lentiviral vectors. In M. Federico (Ed.), Lentivirus Gene Engineering Protocols (2nd ed., pp. 69-76). (Methods in Molecular Biology; Vol. 614). Humana Press. https://doi.org/10.1007/978-1-60761-533-0_4
    • May, T., Butueva, M., Bantner, S., Markusic, D., Seppen, J., MacLeod, R. A. F., Weich, H., Hauser, H., & Wirth, D. (2010). Synthetic gene regulation circuits for control of cell expansion. Tissue Engineering - Part A, 16(2), 441-452. https://doi.org/10.1089/ten.tea.2009.0184
    • Van Hooft, J., Elferink, R. O., & Seppen, J. (2010). Gulzigheid en boete: Laxatiekuren en 'leverstenen'. Nederlands Tijdschrift voor Geneeskunde, 154(51-52), 2391-2393.

    2009

    • Deurholt, T., van Til, N. P., Chhatta, A. A., ten Bloemendaal, L., Schwartlander, R., Payne, C., Plevris, J. N., Sauer, I. M., Chamuleau, R. A. F. M., Oude Elferink, R. P. J., Seppen, J., & Hoekstra, R. (2009). Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. BMC Biotechnology, 9, Article 89. https://doi.org/10.1186/1472-6750-9-89 [details]
    • Markusic, D. M., van Til, N. P., Hiralall, J. K., Oude Elferink, R. P. J., & Seppen, J. (2009). Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain. BMC Biotechnology, 9(1), 85. https://doi.org/10.1186/1472-6750-9-85 [details]
    • Seppen, J., Filali, E. E., & Elferink, R. O. (2009). Small animal models of hepatocyte transplantation. In Hepatocyte Transplantation: Methods and Protocols (pp. 75-82). (Methods in Molecular Biology; Vol. 481). Humana Press. https://doi.org/10.1007/978-1-59745-201-4_7

    2008

    • Boink, G. J. J., Verkerk, A. O., van Amersfoorth, S. C. M., Tasseron, S. J., van der Rijt, R., Bakker, D., Linnenbank, A. C., van der Meulen, J., de Bakker, J. M. T., Seppen, J., & Tan, H. L. (2008). Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer. Journal of Gene Medicine, 10(5), 487-497. https://doi.org/10.1002/jgm.1172
    • van Til, N. P., Heutinck, K. M., van der Rijt, R., Paulusma, C. C., van Wijland, M., Markusic, D. M., Oude Elferink, R. P. J., & Seppen, J. (2008). Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity. Retrovirology, 5, Article 14. https://doi.org/10.1186/1742-4690-5-14

    2007

    • Boink, G. J. J., Seppen, J., De Bakker, J. M. T., & Tan, H. L. (2007). Biological pacing by gene and cell therapy. Netherlands Heart Journal, 15(9), 318-322. https://doi.org/10.1007/BF03086008
    • Boink, G. J. J., Seppen, J., de Bakker, J. M. T., & Tan, H. L. (2007). Gene therapy to create biological pacemakers. Medical and Biological Engineering and Computing, 45(2), 167-176. https://doi.org/10.1007/s11517-006-0112-7
    • Gierman, H. J., Indemans, M. H., Koster, J., Goetze, S., Seppen, J., Geerts, D., van Driel, R., & Versteeg, R. (2007). Domain-wide regulation of gene expression in the human genome. Genome Research, 17(9), 1286-1295. https://doi.org/10.1101/gr.6276007 [details]
    • Markusic, D. M., Kanitz, A., Oude-Elferink, R. P. J., & Seppen, J. (2007). Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64. Human Gene Therapy, 18(7), 673-679. https://doi.org/10.1089/hum.2007.027
    • Vrins, C., Vink, E., Vandenberghe, K. E., Frijters, R., Seppen, J., & Groen, A. K. (2007). The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Letters, 581(24), 4616-4620. https://doi.org/10.1016/j.febslet.2007.08.052

    2006

    • Bonta, P. I., Van Tiel, C. M., Vos, M., Pols, T. W. H., Van Thienen, J. V., Ferreira, V., Arkenbout, E. K., Seppen, J., Spek, C. A., Van Der Poll, T., Pannekoek, H., & De Vries, C. J. M. (2006). Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(10), 2288-2294. https://doi.org/10.1161/01.ATV.0000238346.84458.5d
    • Deurholt, T., Ten Bloemendaal, L., Chhatta, A. A., Van Wijk, A. C. W. A., Weijer, K., Seppen, J., Oude Elferink, R. P. J., Chamuleau, R. A. F. M., & Hoekstra, R. (2006). In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions. Cell transplantation, 15(8-9), 811-822. https://doi.org/10.3727/000000006783464417
    • Seppen, J., Bakker, C., de Jong, B., Kunne, C., van den Oever, K., Vandenberghe, K., de Waart, R., Twisk, J., & Bosma, P. (2006). Adeno-associated Virus Vector Serotypes Mediate Sustained Correction of Bilirubin UDP Glucuronosyltransferase Deficiency in Rats. Molecular Therapy, 13(6), 1085-1092. https://doi.org/10.1016/j.ymthe.2006.01.014
    • Seppen, J., van Til, N. P., van der Rijt, R., Hiralall, J. K., Kunne, C., & Oude Elferink, R. P. J. (2006). Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats. Gene Therapy, 13(8), 672-677. https://doi.org/10.1038/sj.gt.3302681

    2005

    • Barry, S., Brzezinski, M., Yanay, O., Seppen, J. E., & Osborne, W. R. A. (2005). Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery. Journal of Gene Medicine, 7(12), 1510-1516. https://doi.org/10.1002/jgm.807
    • Bot, I., van Eck, M., van Santbrink, P. J., Groot, P. H. E., Hildebrand, R. B., Seppen, J., van Berkel, T. J. C., & Biessen, E. A. L. (2005). Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo. Blood, 106(4), 1147-1153. https://doi.org/10.1182/blood-2004-12-4839 [details]
    • Dekker, R. J., Van Thienen, J. V., Rohlena, J., De Jager, S. C., Elderkamp, Y. W., Seppen, J., De Vries, C. J. M., Biessen, E. A. L., Van Berkel, T. J. C., Pannekoek, H., & Horrevoets, A. J. G. (2005). Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. American Journal of Pathology, 167(2), 609-618. https://doi.org/10.1016/S0002-9440(10)63002-7
    • Markusic, D., Oude-Elferink, R., Das, A. T., Berkhout, B., & Seppen, J. (2005). Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter. Nucleic Acids Research, 33(6), Article e63. https://doi.org/10.1093/nar/gni062 [details]
    • van Til, N. P., Markusic, D. M., van der Rijt, R., Kunne, C., Hiralall, J. K., Vreeling, H., Frederiks, W. M., Oude-Elferink, R. P. J., & Seppen, J. (2005). Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes. Molecular Therapy, 11(1), 26-34. https://doi.org/10.1016/j.ymthe.2004.09.012

    2004

    • Carlotti, F., Bazuine, M., Kekarainen, T., Seppen, J., Pognonec, P., Maassen, J. A., & Hoeben, R. C. (2004). Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Molecular Therapy, 9(2), 209-217. https://doi.org/10.1016/j.ymthe.2003.11.021

    2003

    • Seppen, J., van der Rijt, R., Looije, N., van Til, N. P., Lamers, W. H., & Oude Elferink, R. P. J. (2003). Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer. Molecular Therapy, 8(4), 593-599. https://doi.org/10.1016/S1525-0016(03)00234-X

    2002

    • Seppen, J., Rijnberg, M., Cooreman, M. P., & Oude Elferink, R. P. J. (2002). Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes. Journal of hepatology, 36(4), 459-465. https://doi.org/10.1016/S0168-8278(01)00308-7
    • Weijer, K., Uittenbogaart, C. H., Voordouw, A., Couwenberg, F., Seppen, J., Blom, B., Vyth-Dreese, F. A., & Spits, H. (2002). Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo. Blood, 99(8), 2752-2759. https://doi.org/10.1182/blood.V99.8.2752

    2001

    • Barry, S. C., Harder, B., Brzezinski, M., Flint, L. Y., Seppen, J., & Osborne, W. R. A. (2001). Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression. Human Gene Therapy, 12(9), 1103-1108. https://doi.org/10.1089/104303401750214311
    • Seppen, J., Barry, S. C., Harder, B., & Osborne, W. R. A. (2001). Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin. Blood, 98(3), 594-596. https://doi.org/10.1182/blood.V98.3.594 [details]

    2000

    • Barry, S. C., Seppen, J., Ramesh, N., Foster, J. L., Seyama, K., Ochs, H. D., Garcia, J. V., & Osborne, W. R. A. (2000). Lentiviral and murine retroviral transduction of T cells for expression of human CD40 ligand. Human Gene Therapy, 11(2), 323-332. https://doi.org/10.1089/10430340050016058
    • Seppen, J., Barry, S. C., Klinkspoor, J. H., Katen, L. J., Lee, S. P., Garcia, J. V., & Osborne, W. R. A. (2000). Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors. Journal of Virology, 74(16), 7642-7645. https://doi.org/10.1128/JVI.74.16.7642-7645.2000
    • Seppen, J., Barry, S., Lam, G. M., Ramesh, N., & Osborne, W. R. A. (2000). Retroviral preparations derived from PA317 packaging cells contain inhibitors that copurify with viral particles and are devoid of viral vector RNA. Human Gene Therapy, 11(5), 771-775. https://doi.org/10.1089/10430340050015662

    1999

    • Wei, M. Q., Lejnieks, D. V., Ramesh, N., Lau, S., Seppen, J., & Osborne, W. R. A. (1999). Sustained gene expression in transplanted skin fibroblasts in rats. Gene Therapy, 6(5), 840-844. https://doi.org/10.1038/sj.gt.3300878

    1997

    • Seppen, J., Kimmel, R. J., & Osborne, W. R. A. (1997). Serum-free production, concentration and purification of recombinant retroviruses. BioTechniques, 23(5), 788-790. https://doi.org/10.2144/97235bm04
    • Seppen, J., Tada, K., Ottenhoff, R., Sengupta, K., Chowdhury, N. R., Chowdhury, J. R., Bosma, P. J., & Oude Elferink, R. P. J. (1997). Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: Correction of genetic deficiency and tumor formation. Human Gene Therapy, 8(1), 27-36. https://doi.org/10.1089/hum.1997.8.1-27

    1996

    • Seppen, J., Steenken, E., Lindhout, D., Bosma, P. J., & Oude Elferink, R. P. J. (1996). A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II. FEBS Letters, 390(3), 294-298. https://doi.org/10.1016/0014-5793(96)00677-1
    • Seppen, J., Tada, K., Hellwig, S., Bakker, C. T. M., Prasad, V. R., Roy Chowdhury, N., Roy Chowdhury, J., Bosma, P. J., & Oude Elferink, R. P. J. (1996). Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase. Biochemical Journal, 314(2), 477-483. https://doi.org/10.1042/bj3140477

    1995

    • Seppen, J., Jansen, P. L., & Oude Elferink, R. P. J. (1995). Immunoaffinity purification and reconstitution of the human bilirubin/phenol UDP-glucuronosyltransferase family. Protein Expression and Purification, 6(2), 149-154. https://doi.org/10.1006/prep.1995.1018

    1994

    • Bosma, P. J., Seppen, J., Goldhoorn, B., Bakker, C., Oude Elferink, R. P. J., Chowdhury, J. R., Chowdhury, N. R., & Jansen, P. L. M. (1994). Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. Journal of Biological Chemistry, 269(27), 17960-17964.
    • Seppen, J., Bosma, P. J., Goldhoorn, B. G., Bakker, C. T. M., Chowdhury, J. R., Chowdhury, N. R., Jansen, P. L. M., & Oude Elferink, R. P. J. (1994). Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. Journal of Clinical Investigation, 94(6), 2385-2391. https://doi.org/10.1172/JCI117604

    1992

    • Seppen, J., Ramalho-Santos, J., de Carvalho, A. P., ter Beest, M., Kok, J. W., de Lima, M. C., & Hoekstra, D. (1992). Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration. Biochimica et Biophysica Acta, 1106(1), 209-15. https://doi.org/10.1016/0005-2736(92)90240-m

    2017

    • Botschuijver, S., Roeselers, G., Levin, E., Jonkers, D., Welting, O., Heinsbroek, S., de Weerd, H. H., Boekhout, T., Fornai, M., Masclee, A., de Jonge, W., Seppen, J., & van den Wijngaard, R. M. (2017). Fecal Transplantation and Mycobiome Analysis Showing the Relevance of Fungi in Post Stress Visceral Hypersensitivity of Maternal Separated Rats. Gastroenterology, 152(5, Supplement 1), S160. Article 732. https://doi.org/10.1016/S0016-5085(17)30856-9 [details]

    2004

    2024

    2020

    • Botschuijver, S. (2020). Gut fungi in irritable bowel syndrome: A painful recognition. [Thesis, fully internal, Universiteit van Amsterdam]. [details]

    2019

    2014

    2007

    • van Til, N. P. (2007). Lentiviral gene therapy for the treatment of inherited liver disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
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